TRAZODONE, A TRIAZOLOPYRIDINE DERIVATIVE, IN PRIMARY DEPRESSIVE DISORDER

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (7) , 250-255
Abstract
A double-blind controlled study was conducted to compare the effects of imipramine and placebo with trazodone, a new antidepressant, in 45 hospitalized patients with primary depression. After a 3- to 7-day baseline period, patients were treated for 4 wk. Response was assessed by the Hamilton Psychiatric Scale for Depression, Structured Clinical Interview, Clinical Global Impression, and Global Ward Behavior Scale. The antidepressant effect of trazodone was evident within 7 days of treatment and persisted throughout the study. Patients treated with imipramine also improved, but the response was not as great or as rapid as in the trazodone group.