Allo‐Antigens and Allo‐Antibodies of the Ko System, Serological and Genetic Study

1 January 1973

journal article
Published by Wiley in Vox Sanguinis

Vol. 24 (1) , 1-11
https://doi.org/10.1111/j.1423-0410.1973.tb03851.x

Abstract

Four new cases of anti‐Ko^a allo‐antibodies and a third case of anti‐Ko^b antibody are described. These IgM thromboagglutinating antibodies present a maximum reactivity at 37 °C and at pH 7. The cross‐reaction of anti‐Ko^b antibody with antigen Ko^a is confirmed. Gene and phenotype frequencies of Ko^a and Ko^b alloantigens are determined through a study of 254 Caucasians. Among 63 families, 26 informative families in a double back‐cross situation made it possible to confirm that there is no close linkage between the Ko system and the HL‐A, Rhesus, MNSs, Kell, Duffy and Lewis system.

Keywords

GENETICS

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