Noninvasive Diagnosis of Oral Neoplasia Based on Fluorescence Spectroscopy and Native Tissue Autofluorescence
Open Access
- 1 November 1998
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 124 (11) , 1251-1258
- https://doi.org/10.1001/archotol.124.11.1251
Abstract
PATIENTS WITH cancer of the oral cavity usually present when their disease is already advanced. Treatment for these patients vs those with early-stage disease is more disfiguring and debilitating, more expensive, and less successful. Early detection of neoplastic changes in the oral cavity has great potential for improving the quality of life and survival rates for patients. The goal of this study was to evaluate the clinical applicability of fluorescence spectroscopy (a noninvasive technique for assessing the chemical and morphologic composition of tissue) for the in vivo detection of oral cavity neoplasia.Keywords
This publication has 11 references indexed in Scilit:
- Early Diagnosis of Upper Aerodigestive Tract Cancer by AutofluorescenceJAMA Otolaryngology–Head & Neck Surgery, 1996
- QUANTITATIVE OPTICAL SPECTROSCOPY FOR TISSUE DIAGNOSISAnnual Review of Physical Chemistry, 1996
- Diagnostic fluorescence spectroscopy of oral mucosaPublished by SPIE-Intl Soc Optical Eng ,1995
- Innate tissue fluorescence of the oral mucosa of controls and head-and-neck cancer patientsPublished by SPIE-Intl Soc Optical Eng ,1995
- In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence.Proceedings of the National Academy of Sciences, 1994
- Autofluorescence of normal and malignant bronchial tissueLasers in Surgery and Medicine, 1991
- Use of meta-analysis to evaluate tolonium chloride in oral cancer screeningOral Surgery, Oral Medicine, Oral Pathology, 1989
- Optical spectroscopic diagnosis of cancer and normal breast tissuesJournal of the Optical Society of America B, 1989
- Endogenous porphyrin fluorescence in tumorsLasers in Surgery and Medicine, 1987
- Toluidine blue staining in the detection of oral precancerous and malignant lesionsOral Surgery, Oral Medicine, Oral Pathology, 1984