Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X Chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions
- 1 November 1995
- journal article
- research article
- Published by Springer Nature in Mammalian Genome
- Vol. 6 (11) , 802-804
- https://doi.org/10.1007/bf00539008
Abstract
Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. A human caltractin cDNA (CALT) has recently been mapped by fluorescence in situ hybridization (FISH) to Xq28. We report here refined mapping of the human CALT gene and its murine homolog between the loci DXS1104 (DXHXS1104) and DXS52 (DXHXS52) by PCR and Southern analysis of YACs and somatic cell hybrids from the region in both species. These mapping studies place the gene within the critical region for the murine X-linked dominant, male lethal mutations bare patches and striated.Keywords
This publication has 12 references indexed in Scilit:
- A YAC clone map spanning 7.5 megabases of human chromosome band Xq28Human Molecular Genetics, 1994
- YAC Contig Organization and CpG Island Analysis in Xq28Genomics, 1994
- A 2.3-Mb Yeast Artificial Chromosome Contig Spanning from Gabra3 to G6pd on the Mouse X ChromosomeGenomics, 1994
- Report of the Fifth International Workshop on Human X Chromosome Mapping 1994 (Part 1 of 4)Cytogenetic and Genome Research, 1994
- Molecular cloning and centrosomal localization of human caltractin.Proceedings of the National Academy of Sciences, 1993
- Extension of the physical map in the region of the mouse X chromosome homologous to human Xq28 and identification of an exception to conserved linkageGenomics, 1992
- A 1.6-Mb contig of yeast artificial chromosomes around the human factor VIII gene reveals three regions homologous to probes for the DXS115 locus and two for the DXYS64 locus.1992
- The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reactionGenomics, 1991
- Alu-primed polymerase chain reaction for regional assignment of 110 yeast artificial chromosome clones from the human X chromosome: identification of clones associated with a disease locus.Proceedings of the National Academy of Sciences, 1991
- Isolation of the human chromosomal band Xq28 within somatic cell hybrids by fragile X site breakage.Proceedings of the National Academy of Sciences, 1990