Inflammation, Atherosclerosis, and Ischemic Events — Exploring the Hidden Side of the Moon

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Abstract
Cardiac and cerebral ischemic events develop unpredictably in patients with widely varying degrees of atherosclerotic disease. Thus, a major area of research is the study of the stimuli that provoke ischemic events. The weak relation between ischemic events and flow-limiting stenoses in the coronary and carotid arteries leaves room for innovative research.1 However, it is easier to study the details of accepted paradigms than it is to develop new hypotheses, just as it was easier to map the visible face of the moon than it was to explore its hidden side.The study by Ridker et al. in this issue . . .