Effects of Epsilon Amino Caproic Acid (EACA) on Survival of Fibrinogen I131 and on Fibrinolytic and Coagulation Factors in Dogs.
- 1 December 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 114 (3) , 777-778
- https://doi.org/10.3181/00379727-114-28794
Abstract
Comment and summary The average daily dose of EACA was 9.0 g, a very large amount as compared to the usual human dose of 10 to 20 g per day. In vitro tests (not illustrated) demonstrated that EACA inhibited dog fibrinolysin and SK-activation of profibrinolysin at concentrations of 0.02–0.06%. In the treated dogs the “spontaneous”fibrinolytic activity of the plasma and its euglobulin fraction were significantly lessened. No changes in coagulation factor levels or in survival of fibrinogen I131 were noted.Keywords
This publication has 1 reference indexed in Scilit: