The effect of neurotensin on pituitary secretion of thyrotrophin and prolactin in vitro

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Abstract
The effects of neurotensin on thyrotrophin (TSH) and prolactin (Prl) release were studied in two in vitro systems – anterior pituitary cells in culture and perifused anterior pituitary fragments. Neurotensin significantly reduced basal secretion of both TSH and Prl (P < 0.001) from cultured pituitary cells, and abolished thyrotrophin releasing hormone (TRH)-stimulated TSH release. Neurotensin significantly reduced TRH-stimulated TSH and Prl release (P < 0.02) from perifused pituitary fragments. These data indicate that neurotensin has a direct inhibitory effect on TSH and Prl secretion by the anterior pituitary.