Determination of plasma (1 → 3)-β-d-glucan: A new diagnostic aid to deep mycosis
- 1 January 1992
- journal article
- case report
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 30 (4) , 275-280
- https://doi.org/10.1080/02681219280000361
Abstract
We present additional evidence that plasma from patients with deep-seated mycoses contains (1-->3)-beta-D-glucan. Digestion of such samples with endo-(1-->3)-beta-D-glucanase completely abolished the ability of the plasma to activate factor-G, a horseshoe crab coagulation enzyme that is extremely sensitive to this polysaccharide. Measurement of plasma (1-->3)-beta-D-glucan is a promising method for the diagnosis of deep-seated mycoses and for monitoring the response of these infections to antifungal therapy.Keywords
This publication has 9 references indexed in Scilit:
- Activation of a limulus coagulation factor G by (1 → 3)-g⊝d-glucansCarbohydrate Research, 1991
- Detection of Circulating Candida Enolase by Immunoassay in Patients with Cancer and Invasive CandidiasisNew England Journal of Medicine, 1991
- False-positive result in Limulus test caused by Limulus amebocyte lysate-reactive material in immunoglobulin productsJournal of Clinical Microbiology, 1989
- Endotoxin-inactivating activity in normal and pathological human blood samplesInfection and Immunity, 1986
- A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applicationsClinica Chimica Acta; International Journal of Clinical Chemistry, 1985
- A new (1 → 3)‐β‐D‐glucan‐mediated coagulation pathway found in limulus amebocytesFEBS Letters, 1981
- A Comparison of the Structure of Curdlan and PachymanAgricultural and Biological Chemistry, 1968