Thermoafferent signal processing in rats: an electrophysiological analysis of midbrain influences on thermoresponsive neurons in the ventrobasal thalamus

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Abstract
The influence of electrical midbrain stimulation on thalamic cells which respond to scrotal skin warming with steep increases in firing rate was studied in anaesthetized rats. Square-wave stimuli of 200 μs duration and 30–250 μA intensity at 15 Hz were applied in trains lasting about 1 min. At low scrotal temperatures stimulation of the nucleus raphe dorsalis, the adjacent central grey or the median raphe nucleus was nearly always followed by a rise in thalamic activity. Inhibition occurred only in 4 of 75 experiments. Often midbrain stimulation caused neuronal responses similar to those following scrotal warming. Single stimulation experiments and the combination of electrical stimulation and electrolytic lesions indicated local interactions between excitatory and inhibitory neuronal networks in midbrain. Poststimulus latencies revealed polysynaptic midbrain/thalamic connections. Direct projections with no more than a few synaptic interruptions were seen in about 10% of the experiments. It is concluded that medial midbrain neurons influence the transmission of peripheral thermal information to the specific thalamus and contribute to the typical switching form of thalamic responses to scrotal warming.