Hypothermic Effect of Chlorpromazine, Histamine and Serotonin, and Acclimatization to Cold
- 1 November 1957
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 96 (2) , 482-483
- https://doi.org/10.3181/00379727-96-23514
Abstract
The hypothermic effects of chlorpromazine, serotonin and histamine were investigated in rats in air of 21[degree]C, after acclimatization in 6[degree]C for from 1 to 28 days. The response to chlorpromazine was greatly reduced in animals acclimatized to cold air for 7 and 28 days. Similarly, the fall in body temperature observed with serotonin and histamine was not as pronounced in acclimatized as in control animals.Keywords
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