Malignant Cells in Peripheral Blood

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Abstract
THE fact that malignant tumor cells are sometimes found in the circulating peripheral blood has been demonstrated by several investigators,1 2 3 but the presence of these cells has been thought to be extremely rare. Recent reports, however, indicate that many patients with known cancer have recognizable tumor cells in circulating blood. Engell4 describes definite tumor cells in the peripheral blood of 9.7 per cent of the patients he examined, and "atypical tumor-like cells" in 8.5 per cent. Sandberg and Moore5 report the findings of tumor cells in the peripheral blood of 38 per cent of patients with advanced adenocarcinoma. Both groups . . .

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