Determination of octanol‐water partitioning coefficients (KOW) of 61 organophosphorus and carbamate insecticides and their relationship to respective water solubility (S) values

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Abstract
Octanol-water partitioning coefficients (Kow) were determined for 61 organophosphorus and carbamate insecticides and related compounds at 20.degree. C. In some instances, variations in reported Kow values (including present data) were as great as 180-fold. Despite considerable care in determining Kow values, there remained a number of compounds whose Kow-solubility data points fell some distance off the log Kow/log S regression line, examples being fenamiphos and azinphos-methyl. Such deviations may have been due to several factors including incorrect estimates of the heats of fusion values used in the melting point corrections, and the apparent erratic behavior of the activity coefficients in water-saturated octanol with respect to the activity coefficients in octanol-saturated water. The regression for log Kow vs. log S (corrected for melting points) for 58 compounds was: log Kow = -0.833 log S (corr.) + 0.323, r = 0.975.