Abstract
Toxicology is based on the premise that all compounds are toxic at some dose. Salt, water, sugar, and even a mother’s love produce deleterious effects when given in inappropriate amounts. Thus it is not surprising that very large doses of aspartame (Fig. 1) or aspartame’s component parts (aspartate, phenylalanine, and methanol) produce deleterious effects in sensitive animal species. The critical question is whether the compound is potentially harmful at normal use and potential abuse levels.

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