Mutations in a 23S rRNA Gene of Chlamydia trachomatis Associated with Resistance to Macrolides
Open Access
- 1 April 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (4) , 1347-1349
- https://doi.org/10.1128/aac.48.4.1347-1349.2004
Abstract
For six clinical isolates of Chlamydia trachomatis , in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four isolates were resistant to all the antibiotics and had the mutations A2058C and T2611C ( Escherichia coli numbering) in the 23S rRNA gene. All the isolates had mixed populations of bacteria that did and did not carry 23S rRNA gene mutations.Keywords
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