Serum Glucocorticoids, Growth Hormone and Insulin and Plasma Glucose in Bulls Given Prostaglandin E2 or F2α

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Abstract
Plasma glucose and serum insulin, growth hormone and glucocorticoid concentrations were determined in five yearling bulls given (im) 5, 15 or 30 mg prostaglandin E2(PGE2), 30 mg prostaglandin F2α(PGF2α) or saline. Jugular blood was collected at frequent intervals around the time of injection and at .5—hr intervals from 1 to 9 hr after injections. Thirty milligrams PGE2 and 30 mg PGF2α each caused 15- to 20-fold increases in serum glucocorticoids. Glucocorticoids increased with increasing doses of PGE22. Although PGE2 and PGF2α each increased blood growth hormone, this effect was about twofold larger after PGE2. By contrast, PGE2 depressed serum insulin about 50% for 1 hr, then insulin increased about sixfold until 3 to 4 hours. Blood serum insulin increased after PGF2α, but this effect only approached significance (P<.10). Plasma glucose increased about 10 mg/l00ml after PGE2, but was not affected significantly by PGF2α. Thus, the effects of PGE2 and PGF2α on hormones which control glucose metabolism differ markedly. We speculate that PGE2 caused a twofold increase in growth hormone secretion within 10 to 20 min, that increased growth hormone induced increased blood glucose within 1 to 2 hr and that increased glucose caused increased insulin secretion at 2 to 4 hr, but we cannot rule out a transitory (1 hr) suppressive effect of PGE2 directly on the pancreas. Copyright © 1979. American Society of Animal Science . Copyright 1979 by American Society of Animal Science

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