ELNATED LACTATE DEHYDROGENASE ISOENZYME I AS A TUMOUR MARKER IN PATIENTS WITH GERM CELL TESTICULAR TUMOURS

Publisher Website
Google Scholar
Abstract
In a series of 50 patients with testicular tumours evaluated prior to orchidectomy, 12 out of 19 with pure seminoma and seven out of 31 with non‐seminomatous or mixed seminomatous and non‐seminomatous germ cell tumours had elevated plasma lactate dehydrogenase isoenzyme 1 concentrations. In contrast. seven of the 19 seminoma patients had elevated serum human chorionic gonadotrophin (hCG) concentrations and 25 of the 31 non‐seminomatous and mixed seminomatous and non‐seminomatous gem cell tumour patients had elevations of hCG and/or α‐fetoprotein. Using these three markers, 12 out of 19 seminoma patients and 27 out of 31 non‐seminomatous or mixed seminomatous and non‐seminomatous tumour patients were positive for one or more of these tumour markers.