Reductions in the Activation of ERK and JNK Are Associated with Decreased IL-2 Production in T Cells from Elderly Humans Stimulated by the TCR/CD3 Complex and Costimulatory Signals
- 1 December 1997
- journal article
- Published by Elsevier in Cellular Immunology
- Vol. 182 (2) , 79-88
- https://doi.org/10.1006/cimm.1997.1226
Abstract
No abstract availableKeywords
This publication has 67 references indexed in Scilit:
- Calcium signals in T lymphocytes from old miceLife Sciences, 1996
- T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYSAnnual Review of Immunology, 1996
- Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced ApoptosisJournal of Biological Chemistry, 1996
- Cellular distribution of protein kinase C isozymes in CD3‐mediated stimulation of human T lymphocytes with agingFEBS Letters, 1995
- Activation of ternary complex factor Elk-1 by stress-activated protein kinasesCurrent Biology, 1995
- Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathwayCell, 1994
- SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTESAnnual Review of Biochemistry, 1994
- Accumulation of hyporesponsive, calcium extruding memory T cells as a key feature of age-dependent immune dysfunctionClinical Immunology and Immunopathology, 1991
- Heterogeneity of immune responsiveness in healthy elderly subjectsClinical Immunology and Immunopathology, 1988
- Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.Journal of Clinical Investigation, 1988