Pathogenicity of 5-fluorocytosine resistant strains ofCandida albicans
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 28 (1) , 27-34
- https://doi.org/10.1080/02681219080000041
Abstract
Mutants of Candida albicans blocked in pyrimidine transport and salvage metabolism were produced by a two step mutagenic procedure and selected by their resistance to 5-fluorocytosine (flucytosine). The growth rates and growth yields of these mutants did not differ significantly from the parental strain of C. albicans. Examination of their pathogenicity to mice demonstrated that a defect in the uridine transport function decreased the pathogenicity of C. albicans.This publication has 10 references indexed in Scilit:
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