A new method for the evaluation of the liver injury by 19F MRS of 5‐fluorouracil
- 1 December 1991
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 22 (2) , 499-504
- https://doi.org/10.1002/mrm.1910220257
Abstract
An investigation was made of 5‐fluorouracil metabolism in rat liver by 19F MRS. Fluoronucleotide synthesis increased markedly with liver injury and accelerated with uracil treatment, indicating that 19F MRS may serve as a new method for evaluating liver viability. © 1991 Academic Press, Inc.Keywords
This publication has 9 references indexed in Scilit:
- Direct 19f NMR spectroscopic observation of 5‐fluorouracil metabolism in the isolated perfused mouse liver modelNMR in Biomedicine, 1988
- A31p nuclear magnetic resonance studyin vivo of metabolic abnormalities in rats with acute liver failureNMR in Biomedicine, 1988
- Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapyMagnetic Resonance Imaging, 1987
- 5-Flourouracil metabolism monitored in vivo by 19F NMRBritish Journal of Cancer, 1984
- Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography.Journal of Biological Chemistry, 1982
- Early onset of lipoperoxidation in rat liver after carbon tetrachloride administrationExperimental and Molecular Pathology, 1968
- Lipoperoxidation of Rat Liver Microsomal Lipids induced by Carbon TetrachlorideNature, 1966
- Inhibition of the ethanol and carbon tetrachloride induced fatty liver by antioxidantsExperimental and Molecular Pathology, 1965
- Regeneration of Mammalian LiverPublished by Elsevier ,1963