RELATION OF OBESITY TO THE FUNCTION OF THE THYROID GLAND, ESPECIALLY AS INDICATED BY THE PROTEIN-BOUND IODINE CONCENTRATION IN THE PLASMA

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Abstract
IN 1916 Means (1) reported that even in patients with marked obesity the basal metabolic rate was usually normal. Since then much evidence has accumulated (2) to indicate that hypothyroidism does not play an important role in the etiology of obesity, but this interrelationship has not been clarified completely. In individuals with myxedema there does not tend to be much adiposity. For example, Boothby and Sandiford (3) found in 81 per cent of 94 obese patients that the basal metabolic rate was within 10 per cent of normal. Strouse, Wang and Dye (4) observed that the basal metabolic rate of normal persons was similar, per square meter of body surface, to those of subjects who were overweight. Grafe (5) found a definite decrease in the basal metabolic rate in only 3 of 180 patients with marked obesity. In most of the obese subjects whom we studied (6) the basal metabolic rate was normal.

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