Pharmacology of Non-Sedating H1 Antihistamines
- 1 January 1991
- book chapter
- Published by Springer Nature
- Vol. 33, 181-196
- https://doi.org/10.1007/978-3-0348-7309-3_13
Abstract
A review of the preclinical pharmacology of non-sedating H1 antihistamines includes comparative data on potency, duration of action, side effect liability, especially CNS depressant and anticholinergic activity and new approaches that may further enhance the efficacy of these newer compounds. Data discussed mainly involve studies in which multiple comparative agents were used and usually include astemizole, cetirizine, loratadine and terfenadine. New research approaches include the combination of PAF inhibition with antihistamine activity and the inhibitory effects these compounds may have on cellular influx in allergic diseases.Keywords
This publication has 19 references indexed in Scilit:
- Terfenadine Modifies Airway Narrowing Induced by the Inhalation of Nonisotonic Aerosols in Subjects with AsthmaAmerican Review of Respiratory Disease, 1990
- New antihistaminesClinical and Experimental Allergy, 1989
- Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reactionJournal of Allergy and Clinical Immunology, 1989
- Antiallergic activity of H-receptor antagonists assessed by nasal challengeJournal of Allergy and Clinical Immunology, 1988
- 175 The effect of azelastime (AZ) un neutrophil and eosinophil generation of superoxide (O2−)Journal of Allergy and Clinical Immunology, 1988
- Topical levocabastine, a selective H1 antagonist, in seasonal allergic rhinoconjunctivitisAllergy, 1987
- Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivoClinical and Experimental Allergy, 1987
- Antiallergic activity of loratadine, a non‐sedating antihistamineAllergy, 1986
- Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1‐receptor antagonist with negligible ability to penetrate the central nervous systemBritish Journal of Pharmacology, 1986
- Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamineInflammation Research, 1984