Synthesis, stereochemistry, and isomerisation of α-phenylethylidene-succinic esters and related compounds
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 1483-1487
- https://doi.org/10.1039/p19740001483
Abstract
The lack of stereoselectivity in the Stobbe condensation involving acetophenone or diethyl α-phenylethylidene-succinate can be attributed to E2 elimination through both diastereoisomeric lactone intermediates, base catalysed isomerisation of ester reactant or product(s), or a combination of these reactions.Keywords
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