No evidence of fetal DNA persistence in maternal plasma after pregnancy
- 27 February 2003
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 112 (5-6) , 617-618
- https://doi.org/10.1007/s00439-003-0919-3
Abstract
Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular microchimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.Keywords
This publication has 6 references indexed in Scilit:
- Presence of fetal DNA in maternal plasma decades after pregnancyHuman Genetics, 2002
- Accuracy of Fetal Gender Determination by Analysis of DNA in Maternal PlasmaClinical Chemistry, 2001
- Determination of RhD Zygosity: Comparison of a Double Amplification Refractory Mutation System Approach and a Multiplex Real-Time Quantitative PCR ApproachClinical Chemistry, 2001
- Rapid Clearance of Fetal DNA from Maternal PlasmaAmerican Journal of Human Genetics, 1999
- Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal DiagnosisAmerican Journal of Human Genetics, 1998
- Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum.Proceedings of the National Academy of Sciences, 1996