Mechanism of activation of the antitumor antibiotic neocarzinostatin by mercaptan and sodium borohydride.
- 1 January 1989
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 42 (5) , 761-768
- https://doi.org/10.7164/antibiotics.42.761
Abstract
The structures of meracaptan and sodium borohydride reaction products of neocarzinostatin chromophore A (NCS Chrom A) are compared. Implications on the mechanism of activation of NCS are discussed.This publication has 21 references indexed in Scilit:
- Stoichiometric uptake of molecular oxygen and consumption of sulfhydryl groups by neocarzinostatin chromophore bound to DNA.Journal of Biological Chemistry, 1983
- Neocarzinostatin chromophore: Presence of a highly strained ether ring and its reaction with mercaptan and sodium borohydrideBiochemical and Biophysical Research Communications, 1983
- NEOCARZINOSTATIN CHROMOPHORE - ASSIGNMENT OF SPECTRAL PROPERTIES AND STRUCTURAL REQUIREMENTS FOR BINDING TO DNA1983
- Covalent adducts of DNA and the nonprotein chromophore of neocarzinostatin contain a modified deoxyribose.Proceedings of the National Academy of Sciences, 1982
- Neocarzinostatin chromophore: Presence of a cyclic carbonate subunit and its modification in the structure of other biologically active formsBiochemical and Biophysical Research Communications, 1981
- Stabilization of neocarzinostatin nonprotein chromophore activity by interaction with apoprotein and with HeLa cellsBiochemistry, 1980
- Neocarzinostatin: Chemical characterization and partial structure of the non-protein chromophoreBiochemical and Biophysical Research Communications, 1980
- Roles of chromophore and apo-protein in neocarzinostatin action.Proceedings of the National Academy of Sciences, 1980
- Neocarzinostatin: Spectral characterization and separation of a non-protein chromophoreBiochemical and Biophysical Research Communications, 1979
- Characterization of DNA strand breakage in vitro by the antitumor protein neocarzinostatinBiochemistry, 1977