Animal Experiments on the Role of T Lymphocytes in the Course of Antineoplastic Chemotherapy

Publisher Website
Google Scholar
Abstract
Strain 2 guinea pigs bearing an intradermally growing already lymphogenetically metastasized line 10 tumor received intralesional chemotherapy with either cisplatin or vincristine. After successful treatment with cisplatin and low-dose vincristine, nearly all animals developed tumor-specific immunity. This phenomenon was not observed in animals treated with high-dose vincristine. Possible mechanisms of generation and alteration of primary T-cell-induced posttherapeutic tumor immunity are discussed.

This publication has 0 references indexed in Scilit: