Asymmetric total synthesis of a new non-natural 1β-methoxycarbapenem
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 821-823
- https://doi.org/10.1039/c39890000821
Abstract
The asymmetric total synthesis of the new non-natural 1β-methoxycarbapenem (1) has been achieved via highly diastereoselective alkylation at the C-4 position of 4-acetoxyazetidin-2-one (4) with the tin enolate of thiazolidinethione (3); the stereochemistry has been confirmed by an X-ray crystal structure determination of the derivative (13).Keywords
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