Intranuclear Inclusions in the Submaxillary Gland of the Rat

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Abstract
The salivary glands of 70 rats, all approximately 2 mos. old, were studied histologically and examined for inclusion bodies. The glands were fixed in formaldehyde or Zenkers'' solution and stained with hematoxylin and eosin. Glands of 10 rats showed pathological changes. The specific inclusions were found within the nuclei of cells in the ducts of the submaxillary gland. The histologic changes found are described and compared with the histologic changes in the submaxillary gland of the guinea pig infected with submaxillary virus. It is concluded that the virus is different from that causing the submaxillary lesions of the guinea pig. The findings were suggestive of a seasonal variation or an epizootic. The submaxillary lesion observed in the rat possessed some features in common with the lesions of other virus diseases.