The Response of Plasmodium Malariae Infections to Pyrimethamine (Daraprim)
- 1 March 1957
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 6 (2) , 223-224
- https://doi.org/10.4269/ajtmh.1957.6.223
Abstract
Summary Pyrimethamine was tried 17 times against Plasmodium malariae (USPHS strain) infections in 15 neurosyphilitic patients. The drug was given on one or two days in amounts totaling 25, 50, or 100 mgm. The response of the erythrocytic parasites was comparatively slow with a median of 12 days to clearance in 14 patients. Of 11 patients with an adequate follow-up, seven relapsed. Two patients who had relapsed after 25 mgm. were treated with 50 mgm. The latter dose failed to eliminate the erythrocytic parasites.Keywords
This publication has 2 references indexed in Scilit:
- RESPONSE OF PLASMODIUM MALARIAE INFECTIONS TO THREE DIFFERENT DRUGSJAMA, 1951
- The Efficacy of Chloroquine, Quinacrine, Quinine and Totaquine in the Treatment of Plasmodium Malariae Infections (Quartan Malaria)The American Journal of Tropical Medicine, 1948