Modified oligopeptides designed to interact with the HIV-1 proteinase inhibit viral replication
- 1 September 1990
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 114 (3-4) , 167-173
- https://doi.org/10.1007/bf01310746
Abstract
The human immunodeficiency virus 1 (HIV-1) codes for a proteinase that cuts viral proteins at specific sites. We have tested 13 modified oligopeptides related to these cleavage sites to see if they inhibit viral replication. To indicate whether a decrease in replication could be due to a general inhibition of cell metabolism, we also measured the effect of the peptides on cellular protein synthesis. Three of the peptides tested (Ac-Gln-Asn-Sta-Val-NH2, Ac-Gln-Asn-Sta-Val-Val-NH2, and Ac-Glu-Asn-Sta-Ile-NH2) inhibited HIV-1 replication at concentrations that did not inhibit protein synthesis. Ac-Gln-Asn-Sta-Val-NH2 was the most potent, causing an approximately 40% decrease in viral replication, measured as the synthesis of HIV-1 antigens and the formation of infectious particles.This publication has 37 references indexed in Scilit:
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