FLUORESCENCE MICROLYMPHOGRAPHY ABOVE THE MEDIAL MALLEOLUS IN HEALTHY-VOLUNTEERS AND PATIENTS WITH PRIMARY LYMPHEDEMA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 112  (7) , 225-231
Abstract
Fluorescence microlymphography, a virtually atraumatic procedure, makes it possible to visualize the superficial network of skin lymphatic microvessels. 0.01 ml of a 25% solution of FITC[fluorescein isothiocyanate]-dextran were injected into the subepidermal layer using a steel microneedle (outer diameter 0.2 mm) connected to a microsyringe. The region above the medial ankle was examined by microlymphography in 15 healthy volunteers and 24 patients with primary lymphedema. The mean maximal propagation of the fluorescent dye in the lymphatic network, measured from the original deposit, was significantly lower (P < 0.001) in healthy volunteers (7.8 .+-. 2.6 mm) than in patients with primary lymphedema (22.1 .+-. 13.1 mm). Cutaneous reflux phenomena were demonstrated in 20% of the patients. The number of visualized precollectors was lower in patients with primary lymphedema. No significant differences were found between the mean diameters of meshes and of lymphatic capillaries in healthy volunteers and patients. Definitely enlarged lymphatic vessels were observed in 2 patients with congenital lymphedema.

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