Hypertension following Chronic, Very Low Dose Cadmium Feeding

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Abstract
Exposing female Long-Evans rats to 0.1, 0.25 or 0.5 ppm of Cd in drinking water for 6-18 mo. from the time of weaning induced a statistically significant average increase in systolic pressure of 10 to 24 mm Hg, and there was no evidence of Cd toxicity. Comparable exposure to 0.01 or 0.03 ppm of Cd was much less effective in raising pressure and probably had no pressor effect. After 18 mo. of exposure, the average renal Cd level for the 0.1 ppm Cd group approximated 1 .mu.g/g in contrast to more than 40 .mu.g/g for the standard 5 ppm group and less than 0.1 .mu.g/g for the control group.

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