Evaluation of Platelet Antibodies in Idiopathic Thrombocytopenic Purpura
- 1 February 1962
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 109 (2) , 157-167
- https://doi.org/10.1001/archinte.1962.03620140029006
Abstract
Introduction The suggestion that antibodies to platelets are responsible for the thrombocytopenia of "idiopathic" thrombocytopenic purpura (ITP) is based on three observations: (a) infants born of mothers with ITP sometimes exhibit thrombocytopenia1; (b) normal volunteers who receive infusions of plasma from patients with ITP sometimes develop thrombocytopenia2; (c) transfused platelets do not circulate as long in patients with ITP as in normal recipients.3 These phenomena indicate that a constituent of the blood of some patients with ITP is able to depress platelet levels of normal persons. These observations, however, are not proof of an antigen-antibody reaction, and it is not known whether this platelet-depressing activity is, in fact, capable of affecting the patient's own platelets. Platelet antibodies have been demonstrated in patients with thrombocytopenia induced by drugs, such as allyl-isopropyl-acetyl-carbamide (Sedormid),4 quinidine,5 quinine,6 and novobiocin7; and in patients who have received transfusions.8-10This publication has 0 references indexed in Scilit: