NEUROMUSCULAR FACILITATION AND ASTHENIC SYNAPSES

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Abstract
Facilitation of nerve muscle transmission by repetitive stimulation was usually observed in frog preparation with a wide range of stimulation frequencies and occasionally observed in rat and rabbit muscle at certain range of frequencies. Facilitation was greater following reduction of Ca concentration and less marked following Ca increases in the medium. Double shock experiments on single nerve muscle fibre preparations showed two modes of transmission; the impluse was transmitted by the first as well as the second shock or only by the second shock in the certain shock intervals. Either type could be transferred by changing the Ca concentration, while the time course of the size of the second excitatory post-synaptic potential did not show any difference.

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