Pharmacology of the Psychotherapeutic Drug Benactyzine ( -Diethyl-aminoethyl Benzilate Hydrochloride)

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Abstract
Summary Benactyzine (β-diethylaminoethyl benzilate hydrochloride) an antispasmodic that has been used in the treatment of psychoneuroses causes hyperexcitability and clonic convulsions in animals. A taming effect was not observed. Hesobarbital anesthesia was markedly prolonged. the effects of acetylcholine on the isolated gut and blood pressure diminished and the action of epinephrine on blood pressure enhanced by this compound. Spinal reflexes were not affected and cortical and subcortical electrical activity was slowed. Mice receiving benactyzine often died during electroshock seizures which were tolerated by normal animals.