Long-Term, Pulsatile, Low Dose, Subcutaneous Luteinizing Hormone-Releasing Hormone Administration in Men with Idiopathic Oligozoospermia Failure of Therapeutic and Hormonal Response

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Abstract
In 4 normal men with a history of long standing infertility, severely disturbed sperm qualities (determined in at least 3 spermiograms), normal serum luteinizing hormone (LH) and FSH levels (measured over a time period of 90 min) and lack of evidence of further andrological or other obvious endocrine disorders the effectiveness of LHRH treatment was investigated. LHRH was administered s.c. with a portable, comterized infusion pump (Zyclomat) for 3 mo., with administration intervals of 90 min and bolus dosages of 5 .mu.g (3 patients) and 20 .mu.g (1 patient). Semen qualities during and after LHRH treatment, as compared to pretreatment values, showed no improvement in volume of ejaculate, number of sperms per ml and motility. During or at the end of the treatment period no evident differences were observed in serum LH, FSH and testosterone levels (measured over a 90 min period) compared with hormonal values before LHRH therapy, nor at the low-dose (5 .mu.g) neither at the high-dose (20 .mu.g) administration schedule. Apparently, pulsatile s.c. LHRH treatment in normogonadotropic, oligozoospermic men does not seem to improve the therapeutical arsenal.

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