Animal Models for Schizophrenia: The Hippocampally Lesioned Animal
Open Access
- 1 January 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Schizophrenia Bulletin
- Vol. 13 (2) , 317-327
- https://doi.org/10.1093/schbul/13.2.317
Abstract
Animals with hippocampal lesions are evaluated as models for schizophrenia according to the criteria of McKinney and Bunney (1969). They seem to comply adequately with the following requirements: (1) similarity of inducing conditions; (2) similarity of behavioral states; (3) similarity of underlying neurobiological mechanisms; and (4) reversibility by usual pharmacological treatment. The model seems adequate to reproduce several symptoms of the disorder, offering a good experimental tool for the analysis of its inducing conditions, affected neurobiological mechanisms, and clinical treatment.Keywords
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