ATTENUATED DEVELOPMENT OF RENAL-HYPERTENSION IN ESSENTIAL FATTY ACID-DEFICIENT RATS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 265  (1) , 103-114
Abstract
Renal hypertension (one-clip, 2 kidney) developed to a lower level in essential fatty acid (EFA)-deficient rats than in controls on a complete diet. Body wt gain was the same in both clipped groups. Hypertension in rats on an EFA-deficient diet supplemented with linoleic acid (corn oil) was comparable to that in rats on a complete diet. Plasma renin activity was significantly higher in both hypertensive groups. In the EFA-deficient groups the difference between hypertensive and sham-operated rats was 63% less than in the control groups. Indomethacin potentiated the development of renal hypertension of the control group. Addition of 3.5% linoleic acid (corn oil) to a complete diet blunted the development of hypertension. In the EFA-deficient rats, a lack of endogenous prostaglandin biosynthesis is apparently not responsible for the attenuated developemnt of renal hypertension.