Trimethoprim-Sulfamethoxazole in the Treatment of Typhoid and Paratyphoid Fevers
- 1 November 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 128 (Supplement) , S734-S737
- https://doi.org/10.1093/infdis/128.supplement_3.s734
Abstract
A trial was conducted in naturally-occurring disease to compare the efficacy of treatment with trimethoprim-sulfamethoxazole (TMP-SMZ) with oral chloramphenicol. The majority of patients treated with TMP-SMZ (79%) responded just as well as did those treated with oral chloramphenicol, as measured by time of disappearance of fever after therapy. Seven patients treated with TMP-SMZ, however, failed to respond after 11 or more days of treatment. Neither levels of drug in serum nor in vitro sensitivity tests of the isolated $ISalmonella$N could account for the slow response of these patients to TMP-SMZ.Keywords
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