Efficacy of Staphylococcal Vaccines to Elicit Antistaphylococcal Alpha-Hemolysin in Dairy Cows

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Abstract
Five staphylococcal vaccines containing standardized baeterin and toxoid but dif- ferent adjuvants were prepared to deter- mine the efficacy in eliciting antistaphylo- coecal alpha-hemolysin in dairy cows. The vaccine containing Freund's complete ad- juvant was clearly the most efficacious. There were no significant differences among efficaeics of vaccines containing either no adjuvant, alum, Freund's incomplete ad- juvant, or sodium alginate. After practical antimierobial agents became generally available, their use against bovine mastitis was accompanied often by a shift from streptococcal to staphylococcal etiology. Mur- ray (8) has documented a perhaps typical oc- currence in Michigan. This etiological change has dampened the hopes for eradication of mastitis, because no known antimierobial agent gives the complete control of staphylococcal mastitis as that afforded by penicillin for streptococcal mastitis. The increased prevalence of staphylococcal mastitis and the lack of anti- microbial agents to eradicate staphylococci from cows' udders have prompted new work to- ward immunizing cows against staphylococcal mastitis.

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