Crohnʼs colitis with carcinoma and dysplasia

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Abstract
A patient who developed invasive adenocarcinoma of the cecum after a 20-yr history of Crohn''s enterocolitis is reported. Histologic examination of the resected specimen showed widespread severe dysplasia in addition to the invasive carcinoma. An additional 100 randomly selected bowel resection specimens removed for Crohn''s disease were reviewed to determine the frequency of epithelial dysplasia. Under rigorous criteria, a 2% incidence of mild dysplasia was found; no instance of severe dysplasia was identified.