Surfactant Protein D Increases Fusion ofMycobacterium tuberculosis- Containing Phagosomes with Lysosomes in Human Macrophages

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Abstract
Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst.

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