Structure-Based Development of Anticancer Drugs
- 1 August 2001
- Vol. 9 (8) , 659-667
- https://doi.org/10.1016/s0969-2126(01)00636-0
Abstract
No abstract availableKeywords
This publication has 24 references indexed in Scilit:
- Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues11This work is dedicated to the memory of Professor Lars Ernster, who provided us with enthusiastic support, scientific insight, and constant encouragement in our many interactions.Free Radical Biology & Medicine, 2000
- Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: Species comparison and structural changes with substrate binding and releaseProceedings of the National Academy of Sciences, 2000
- Crystal Structure of Human DT-diaphorase: A Model for Interaction with the Cytotoxic Prodrug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)Journal of Medicinal Chemistry, 1999
- Bioreductive Activation of a Series of Indolequinones by Human DT-Diaphorase: Structure−Activity RelationshipsJournal of Medicinal Chemistry, 1999
- Molecular Characterization of Binding of Substrates and Inhibitors to DT-Diaphorase: Combined Approach Involving Site-Directed Mutagenesis, Inhibitor-Binding Analysis, and Computer ModelingMolecular Pharmacology, 1999
- Molecular Basis of the Catalytic Differences among DT-diaphorase of Human, Rat, and MouseJournal of Biological Chemistry, 1997
- The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.Proceedings of the National Academy of Sciences, 1995
- Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymic reduction by DT-diaphoraseBiochemistry, 1992
- Treatment of patients with recurrent primary brain tumors with AZQNeurology, 1984
- Soluble Diaphorase in Animal Tissues.Acta Chemica Scandinavica, 1958