Characterization of sister chromatid exchange induction by 8-methoxypsoralen plus near UV light

31 December 1977

journal article
research article
Published by S. Karger AG in Cytogenetic and Genome Research

Vol. 21 (4) , 184-200
https://doi.org/10.1159/000130896

Abstract

The combination of 8-methoxypsoralen and near UV light is highly effective in inducing sister chromatid exchanges (SCEs) in Chinese hamster ovary cells. Appreciable increases in SCEs can be effected by treatments compatible with cell survival, and effects of a single dose of alkylation persist over multiple generations. Both the frequency and location of SCEs induced at different times within the DNA synthesis period varies in a manner indicating that exchange induction is restricted to regions which replicated during or after DNA damage.

Keywords

This publication has 20 references indexed in Scilit:

Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. II. In vitro test for compounds requiring metabolic activation
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
8-Methoxypsoralen And Uva Promote Sister-Chromatid Exchanges
Journal of Investigative Dermatology, 1976
Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.
Proceedings of the National Academy of Sciences, 1976
Cross-Linking of DNA in Situ as a Probe for Chromatin Structure
Science, 1976
S phase synchrony in monolayer CHO cultures
Experimental Cell Research, 1976
A Manyfold Increase in Sister Chromatid Exchanges in Bloom's Syndrome Lymphocytes
Proceedings of the National Academy of Sciences, 1974
PHOTOREACTIONS AT 3655Å BETWEEN PYRIMIDINE BASES AND SKIN‐PHOTOSENSITIZING FUROCOUMARINS
Photochemistry and Photobiology, 1967
Hydroquinone and psoralens in the therapy of hypermelanosis and vitiligo
Archives of Dermatology, 1966
GENETICS OF SOMATIC MAMMALIAN CELLS
The Journal of Experimental Medicine, 1958
THE EFFECT OF OXYPSORALEN UPON ULTRAVIOLET CARCINOGENESIS IN ALBINO MICE
1957