Onset of dementia is associated with apolipoprotein E ε4 in Down's syndrome

1 November 1996

journal article
research article
Published by Wiley in Annals of Neurology

Vol. 40 (5) , 799-801
https://doi.org/10.1002/ana.410400518

Abstract

We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of β‐amyloid deposition.

Keywords

This publication has 11 references indexed in Scilit:

Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein
New England Journal of Medicine, 1995
A case—control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome
Annals of Neurology, 1995
Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).
Proceedings of the National Academy of Sciences, 1995
Apolipoprotein E ε2 allele promotes longevity and protects patients with Downʼs syndrome from dementia
NeuroReport, 1994
ApoE genotype and Down's syndrome
The Lancet, 1994
The apolipoprotein ε4 allele in patients with Alzheimer's disease
Annals of Neurology, 1993
Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
The Lancet, 1993
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Proceedings of the National Academy of Sciences, 1993
A Prospective Study of Alzheimer Disease in Down Syndrome
Archives of Neurology, 1989
Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
New England Journal of Medicine, 1989