Synthesis of 5-chloro-3'-nitro-4'-substituted salicylanilides, a new series of anthelmintic and antimicrobial agents

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Abstract
A number of 5-chloro-3''-nitro-4''-substituted salicylanilides were synthesized by treating 4'',5-dichloro-3''-nitrosalicylanilide with various sodium aryl oxides, alkoxides or amines. These compounds were tested against Hymenolepis nana infection in rats and also evaluated for their in vitro antimicrobial activity against various strains of bacteria and fungi. In the former test, the most active cestodicidal agent showed activity at 30 mg/kg. In the antimicrobial screening, one compound inhibited the growth of all the bacteria and fungi used while another was active against the pencillin resistant Staphylococcus aureus at a minimum inhibitory concentration of 0.00609 .mu.g/ml.

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