Gastrointestinal Absorption with Oleic Acid-I131 and L-Methionine-S35 in Patients with Ulcerative Colitis.

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Abstract
Control subjects (patients without gastrointestinal disease) and patients with ulcerative colitis in varying stages of activity were given orally oleic acid-I131 and methionine-S35. Seventy-two hour fecal excretion of I131 and S35 are reported for 71 studies in 37 subjects. Following oral administration of oleic acid-I131 patients with ulcerative colitis showed increased fecal excretion of I131 during the acute phase of the disease, but it returned toward control values as the patients improved clinically. Following administration of methionine-S35, fecal excretion of S35 increased during the acute phase of the disease to a greater degree than the excretion of I131. Also, as the patients improved clinically excretion in the feces returned toward control values only slowly, with the result that during the remission stage of the disease excretion of S35 was still elevated and it was elevated in all ulcerative colitis patients studied to date including those with ileostomy and colectomy.

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