A mouse plasma peptide atlas as a resource for disease proteomics
Open Access
- 3 June 2008
- journal article
- method
- Published by Springer Nature in Genome Biology
- Vol. 9 (6) , R93
- https://doi.org/10.1186/gb-2008-9-6-r93
Abstract
We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.Keywords
This publication has 36 references indexed in Scilit:
- Integrated Pipeline for Mass Spectrometry-Based Discovery and Confirmation of Biomarkers Demonstrated in a Mouse Model of Breast CancerJournal of Proteome Research, 2007
- Analysis of the Mouse Liver Proteome Using Advanced Mass SpectrometryJournal of Proteome Research, 2007
- Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancersNature, 2007
- Of mice and men: Cancer gene discovery using comparative oncogenomicsCancer Cell, 2006
- Using Annotated Peptide Mass Spectrum Libraries for Protein IdentificationJournal of Proteome Research, 2006
- Mass Spectrometry-Based Study of the Plasma Proteome in a Mouse Intestinal Tumor ModelJournal of Proteome Research, 2006
- Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis GeneCell, 2006
- Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic ApproachCell, 2006
- An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysisNature Genetics, 2004
- Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database SearchAnalytical Chemistry, 2002