In Search of a Platelet Coombs Test

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Abstract
Between the years 1945 and 1951, two developments in the growing field of immunohematology were particularly critical. In 1945 Coombs et al. used a rabbit serum against human globulin to produce agglutination of red cells that had been sensitized by the presence of immunoglobulin on their surface.1 Before that time, there had been no dependable method to identify the presence of such immunoglobulin. In the introductory paragraph of their report they stated, "The test was originally intended as an instrument of research; but it promises to be of practical use. . . ." Indeed, it has been. One year later, . . .