SPECIFIC PROLIFERATIVE RESPONSE OF HUMAN-LYMPHOCYTES TO PURIFIED SOLUBLE-ANTIGENS FROM PLASMODIUM-FALCIPARUM INVITRO CULTURES AND TO ANTIGENS FROM MALARIA PATIENTS SERA

  • 1 January 1985
    • journal article
    • research article
    • Vol. 59  (2) , 421-426
Abstract
Antigens of P falciparum in supernatants of in vitro cultures of the parasite were affinity purified on columns prepared with the IgG fraction of the serum of an immune individual. The purified antigens induced proliferation of lymphocytes from persons who had recently had malaria. The responses were strongest with lymphocytes from individuals infected with P. falciparum and P. ovale malaria; P. vivax malaria infections induced a lower level of response and lymphocytes of unsensitized individuals were little affected. Lymphocytes from unsensitized individuals did not respond to the affinity purified antigen preparations from malaria patients''s sera, indicating that significant amounts of non-specific mitogens were not present.