The preparation and isomerization of platinum metronidazole complexes: X-ray crystal and molecular structures of cis- and trans-dichlorobis[1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole]-platinum(II)
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 8,p. 432-433
- https://doi.org/10.1039/c39830000432
Abstract
cis-Pt(Metronidazole)2Cl2, a radiosensitizer toward hypoxic tumour cells, has been prepared and quantitatively isomerizes at its melting point to the trans complex; co-ordination of metronidazole to platinum(II) increases the polarographic reduction potential, and in both isomers the imidazole rings are tilted (69–75°) relative to the Pt(N)2Cl2 square-plane as shown by X-ray crystallography.Keywords
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